
				
				 
				
				In this talk, I would like to 
				speculate a little, on the development of Life in The 
				Universe, and in particular, the development of 
				Intelligent Life. 
				 
				
				I shall take this to include the 
				human race, even though much of its behavior through out 
				history, has been pretty stupid, and not calculated to aid the 
				survival of the species. 
				 
				
				Two questions I shall discuss are,
				
				
					
				
				
				It is a matter of common experience, 
				that things get more disordered and chaotic with time. 
				
				 
				
				This observation can be elevated to 
				the status of a law, the so-called 
				
				Second Law of Thermodynamics. 
				This says that the total amount of disorder, or 
				entropy, in the universe, always increases with time. 
				However, the Law refers only to the total amount of disorder.
				
				 
				
				The order in one body can increase, 
				provided that the amount of disorder in its surroundings 
				increases by a greater amount. This is what happens in a living 
				being. 
				 
				
				One can define Life to be an ordered 
				system that can sustain itself against the tendency to disorder, 
				and can reproduce itself. That is, it can make similar, but 
				independent, ordered systems. To do these things, the system 
				must convert energy in some ordered form, like food, sunlight, 
				or electric power, into disordered energy, in the form of heat. 
				In this way, the system can satisfy the requirement that the 
				total amount of disorder increases, while, at the same time, 
				increasing the order in itself and its offspring. 
				 
				
				A living being usually has two 
				elements: 
				
					
				
				
				In biology, these two parts are 
				called genes and metabolism. But it is worth 
				emphasizing that there need be nothing biological about them.
				
				 
				
				For example, a computer virus is a 
				program that will make copies of itself in the memory of a 
				computer, and will transfer itself to other computers. 
				
				 
				
				Thus it fits the definition of a 
				living system, that I have given. Like a biological virus, 
				it is a rather degenerate form, because it contains only 
				instructions or genes, and doesn't have any metabolism of its 
				own. Instead, it reprograms the metabolism of the host computer, 
				or cell. Some people have questioned whether viruses should 
				count as life, because they are parasites, and can not exist 
				independently of their hosts. 
				 
				
				But then most forms of life, 
				ourselves included, are parasites, in that they feed off and 
				depend for their survival on other forms of life. I think 
				computer viruses should count as life. Maybe it says something 
				about human nature, that the only form of life we have created 
				so far is purely destructive. Talk about creating life in our 
				own image. 
				 
				
				I shall return to electronic forms 
				of life later on.
				
				What we normally think of as 'life' is based on chains of carbon 
				atoms, with a few other atoms, such as nitrogen or phosphorous. 
				One can speculate that one might have life with some other 
				chemical basis, such as silicon, but carbon seems the most 
				favorable case, because it has the richest chemistry. 
				
				 
				
				That carbon atoms should exist at 
				all, with the properties that they have, requires a fine 
				adjustment of physical constants, such as the QCD scale, the 
				electric charge, and even the dimension of space-time. If these 
				constants had significantly different values, either the nucleus 
				of the carbon atom would not be stable, or the electrons would 
				collapse in on the nucleus. At first sight, it seems remarkable 
				that the universe is so finely tuned. Maybe this is evidence, 
				that the universe was specially designed to produce the human 
				race. 
				 
				
				However, one has to be careful about 
				such arguments, because of what is known as the Anthropic 
				Principle. This is based on the self-evident truth, that if 
				the universe had not been suitable for life, we wouldn't be 
				asking why it is so finely adjusted. One can apply the 
				
				Anthropic Principle, in 
				either its Strong, or Weak, versions. 
				 
				
				For the 
				
				Strong Anthropic Principle, 
				one supposes that there are many different universes, each with 
				different values of the physical constants. In a small number, 
				the values will allow the existence of objects like carbon 
				atoms, which can act as the building blocks of living systems.
				
				 
				
				Since we must live in one of these 
				universes, we should not be surprised that the physical 
				constants are finely tuned. If they weren't, we wouldn't be 
				here. The strong form of the Anthropic Principle is not very 
				satisfactory. 
				 
				
				What operational meaning can one 
				give to the existence of all those other universes? And if they 
				are separate from our own universe, how can what happens in 
				them, affect our universe. 
				 
				
				Instead, I shall adopt what is known 
				as the 
				
				Weak Anthropic Principle. 
				That is, I shall take the values of the physical constants, as 
				given. 
				 
				
				But I shall see what conclusions can 
				be drawn, from the fact that life exists on this planet, at this 
				stage in the history of the universe.
				
				There was no carbon, when the universe began in the Big Bang, 
				about 15 billion years ago. It was so hot, that all the matter 
				would have been in the form of particles, called protons and 
				neutrons. There would initially have been equal numbers of 
				protons and neutrons. However, as the universe expanded, it 
				would have cooled. 
				 
				
				About a minute after the Big Bang, 
				the temperature would have fallen to about a billion degrees, 
				about a hundred times the temperature in the Sun. At this 
				temperature, the neutrons will start to decay into more protons. 
				If this had been all that happened, all the matter in the 
				universe would have ended up as the simplest element, hydrogen, 
				whose nucleus consists of a single proton. 
				 
				
				However, some of the neutrons 
				collided with protons, and stuck together to form the next 
				simplest element, helium, whose nucleus consists of two protons 
				and two neutrons. 
				 
				
				But no heavier elements, like carbon 
				or oxygen, would have been formed in the early universe. It is 
				difficult to imagine that one could build a living system, out 
				of just hydrogen and helium, and anyway the early universe was 
				still far too hot for atoms to combine into molecules.
				
				The universe would have continued to expand, and cool. But some 
				regions would have had slightly higher densities than others. 
				The gravitational attraction of the extra matter in those 
				regions, would slow down their expansion, and eventually stop 
				it. 
				 
				
				Instead, they would collapse to form 
				galaxies and stars, starting from about two billion years after 
				the Big Bang. Some of the early stars would have been more 
				massive than our Sun. 
				 
				
				They would have been hotter than the 
				Sun, and would have burnt the original hydrogen and helium, into 
				heavier elements, such as carbon, oxygen, and iron. This could 
				have taken only a few hundred million years. After that, some of 
				the stars would have exploded as supernovas, and scattered the 
				heavy elements back into space, to form the raw material for 
				later generations of stars.
				
				Other stars are too far away, for us to be able to see directly, 
				if they have planets going round them. But certain stars, called 
				pulsars, give off regular pulses of radio waves. We observe a 
				slight variation in the rate of some pulsars, and this is 
				interpreted as indicating that they are being disturbed, by 
				having Earth sized planets going round them. 
				 
				
				Planets going round pulsars are 
				unlikely to have life, because any living beings would have been 
				killed, in the supernova explosion that led to the star becoming 
				a pulsar. But, the fact that several pulsars are observed to 
				have planets suggests that a reasonable fraction of the hundred 
				billion stars in our galaxy may also have planets. The necessary 
				planetary conditions for our form of life may therefore have 
				existed from about four billion years after the Big Bang.
				
				Our solar system was formed about four and a half billion years 
				ago, or about ten billion years after the Big Bang, from 
				gas contaminated with the remains of earlier stars. The Earth 
				was formed largely out of the heavier elements, including carbon 
				and oxygen. Somehow, some of these atoms came to be arranged in 
				the form of molecules of DNA. 
				 
				
				This has the famous double helix 
				form, discovered by Crick and Watson, in a hut on 
				the New Museum site in Cambridge. Linking the two chains in the 
				helix, are pairs of nucleic acids. There are four types of 
				nucleic acid, adenine, cytosine, guanine, and thiamine. I'm 
				afraid my speech synthesizer is not very good, at pronouncing 
				their names. Obviously, it was not designed for molecular 
				biologists. 
				 
				
				An adenine on one chain is always 
				matched with a thiamine on the other chain, and a guanine with a 
				cytosine. 
				 
				
				Thus the sequence of nucleic acids 
				on one chain defines a unique, complementary sequence, on the 
				other chain. The two chains can then separate and each act as 
				templates to build further chains. Thus DNA molecules can 
				reproduce the genetic information, coded in their sequences of 
				nucleic acids. Sections of the sequence can also be used to make 
				proteins and other chemicals, which can carry out the 
				instructions, coded in the sequence, and assemble the raw 
				material for DNA to reproduce itself.
				
				We do not know how DNA molecules first appeared. 
				The chances against a DNA molecule arising by random 
				fluctuations are very small. Some people have therefore 
				suggested that life came to Earth from elsewhere, and that there 
				are seeds of life floating round in the galaxy. However, it 
				seems unlikely that DNA could survive for long in the radiation 
				in space. 
				 
				
				And even if it could, it would not 
				really help explain the origin of life, because the time 
				available since the formation of carbon is only just over double 
				the age of the Earth.
				
				One possibility is that the formation of something like DNA, 
				which could reproduce itself, is extremely unlikely. However, in 
				a universe with a very large, or infinite, number of stars, one 
				would expect it to occur in a few stellar systems, but they 
				would be very widely separated. The fact that life happened to 
				occur on Earth, is not however surprising or unlikely. 
				
				 
				
				It is just an application of the 
				Weak Anthropic Principle: if life had appeared instead on 
				another planet, we would be asking why it had occurred there.
				
				If the appearance of life on a given planet was very unlikely, 
				one might have expected it to take a long time. More precisely, 
				one might have expected life to appear just in time for the 
				subsequent evolution to intelligent beings, like us, to have 
				occurred before the cut off, provided by the life time of the 
				Sun. This is about ten billion years, after which the Sun will 
				swell up and engulf the Earth. An intelligent form of life, 
				might have mastered space travel, and be able to escape to 
				another star. 
				 
				
				But otherwise, life on Earth would 
				be doomed.
				
				There is fossil evidence, that there was some form of life on 
				Earth, about three and a half billion years ago. This may have 
				been only 500 million years after the Earth became stable and 
				cool enough, for life to develop. But life could have taken 7 
				billion years to develop, and still have left time to evolve to 
				beings like us, who could ask about the origin of life. If the 
				probability of life developing on a given planet, is very small, 
				why did it happen on Earth, in about one 14th of the time 
				available.
				
				The early appearance of life on Earth suggests that 
				there's a good chance of the spontaneous generation of 
				life, in suitable conditions. Maybe there was some simpler form 
				of organization, which built up DNA. Once DNA appeared, it would 
				have been so successful, that it might have completely replaced 
				the earlier forms. We don't know what these earlier forms would 
				have been. 
				 
				
				One possibility is
				
				RNA. This is like DNA, but 
				rather simpler, and without the double helix structure. Short 
				lengths of RNA, could reproduce themselves like DNA, and might 
				eventually build up to DNA. One can not make nucleic acids in 
				the laboratory, from non-living material, let alone RNA. But 
				given 500 million years, and oceans covering most of the Earth, 
				there might be a reasonable probability of RNA, being made by 
				chance.
				
				As DNA reproduced itself, there would have been random errors. 
				Many of these errors would have been harmful, and would have 
				died out. Some would have been neutral. That is they would not 
				have affected the function of the gene. Such errors would 
				contribute to a gradual genetic drift, which seems to occur in 
				all populations. And a few errors would have been favorable to 
				the survival of the species. These would have been chosen by 
				Darwinian natural selection.
				
				The process of biological evolution was very slow at first. It 
				took two and a half billion years, to evolve from the earliest 
				cells to multi-cell animals, and another billion years to evolve 
				through fish and reptiles, to mammals. But then evolution seemed 
				to have speeded up. It only took about a hundred million years, 
				to develop from the early mammals to us. 
				 
				
				The reason is, fish contain most of 
				the important human organs, and mammals, essentially all of 
				them. All that was required to evolve from early mammals, like 
				lemurs, to humans, was a bit of fine-tuning.
				
				But with the human race, evolution reached a critical stage, 
				comparable in importance with the development of DNA. This was 
				the development of language, and particularly written language. 
				It meant that information can be passed on, from generation to 
				generation, other than genetically, through DNA. 
				 
				
				There has been no detectable change 
				in human DNA, brought about by biological evolution, in the ten 
				thousand years of recorded history. But the amount of knowledge 
				handed on from generation to generation has grown enormously. 
				The DNA in human beings contains about three billion nucleic 
				acids. However, much of the information coded in this sequence, 
				is redundant, or is inactive. So the total amount of useful 
				information in our genes, is probably something like a hundred 
				million bits. 
				 
				
				One bit of information is the answer 
				to a yes no question. By contrast, a paper back novel might 
				contain two million bits of information. So a human is 
				equivalent to 50 Mills and Boon romances. A major national 
				library can contain about five million books, or about ten 
				trillion bits. So the amount of information handed down in 
				books, is a hundred thousand times as much as in DNA.
				
				Even more important, is the fact that the information in books, 
				can be changed, and updated, much more rapidly. It has taken us 
				several million years to evolve from the apes. 
				 
				
				During that time, the useful 
				information in our DNA, has probably changed by only a few 
				million bits. So the rate of biological evolution in humans, is 
				about a bit a year. By contrast, there are about 50,000 new 
				books published in the English language each year, containing of 
				the order of a hundred billion bits of information. Of course, 
				the great majority of this information is garbage, and no use to 
				any form of life. But, even so, the rate at which useful 
				information can be added is millions, if not billions, higher 
				than with DNA.
				
				This has meant that we have entered a new phase of evolution. At 
				first, evolution proceeded by natural selection, from random 
				mutations. This Darwinian phase, lasted about three and a 
				half billion years, and produced us, beings who developed 
				language, to exchange information. But in the last ten thousand 
				years or so, we have been in what might be called, an external 
				transmission phase. In this, the internal record of information, 
				handed down to succeeding generations in DNA, has not changed 
				significantly. 
				 
				
				But the external record, in books, 
				and other long lasting forms of storage, has grown enormously. 
				Some people would use the term, evolution, only for the 
				internally transmitted genetic material, and would object to it 
				being applied to information handed down externally. But I think 
				that is too narrow a view. We are more than just our genes.
				
				 
				
				We may be no stronger, or inherently 
				more intelligent, than our cave man ancestors. But what 
				distinguishes us from them, is the knowledge that we have 
				accumulated over the last ten thousand years, and particularly, 
				over the last three hundred. 
				 
				
				I think it is legitimate to take a 
				broader view, and include externally transmitted information, as 
				well as DNA, in the evolution of the human race.
				
				The time scale for evolution, in the external transmission 
				period, is the time scale for accumulation of information. This 
				used to be hundreds, or even thousands, of years. But now this 
				time scale has shrunk to about 50 years, or less. On the other 
				hand, the brains with which we process this information have 
				evolved only on the Darwinian time scale, of hundreds of 
				thousands of years. 
				 
				
				This is beginning to cause problems. 
				In the 18th century, there was said to be a man who had read 
				every book written. But nowadays, if you read one book a day, it 
				would take you about 15,000 years to read through the books in a 
				national Library. By which time, many more books would have been 
				written.
				
				This has meant that no one person can be the master of more than 
				a small corner of human knowledge. People have to specialize, in 
				narrower and narrower fields. This is likely to be a major 
				limitation in the future. We certainly can not continue, for 
				long, with the exponential rate of growth of knowledge that we 
				have had in the last three hundred years. 
				 
				
				An even greater limitation and 
				danger for future generations, is that we still have the 
				instincts, and in particular, the aggressive impulses, that we 
				had in cave man days. Aggression, in the form of subjugating or 
				killing other men, and taking their women and food, has had 
				definite survival advantage, up to the present time. 
				 
				
				But now it could destroy the entire 
				human race, and much of the rest of life on Earth. A
				
				nuclear war, is still the most 
				immediate danger, but there are others, such as the
				
				release of a genetically engineered virus. 
				Or the green house effect becoming unstable.
				
				There is no time, to wait for 
				
				Darwinian evolution, to 
				make us more intelligent, and better natured. But we are now 
				entering a new phase, of what might be called, self designed 
				evolution, in which we will be able to change and improve 
				our DNA. 
				 
				
				There is a project now on, to map
				
				the entire sequence of human DNA.
				
				 
				
				It will cost a few billion dollars, 
				but that is chicken feed, for a project of this importance. Once 
				we have read the book of life, we will start writing in 
				corrections. At first, these changes will be confined to the 
				repair of genetic defects, like cystic fibrosis, and muscular 
				dystrophy. These are controlled by single genes, and so are 
				fairly easy to identify, and correct. 
				 
				
				Other qualities, such as 
				intelligence, are probably controlled by a large number of 
				genes. It will be much more difficult to find them, and work out 
				the relations between them. Nevertheless, I am sure that during 
				the next century, people will discover how to modify both 
				intelligence, and instincts like aggression.
				
				Laws will be passed, against genetic engineering with humans. 
				But some people won't be able to resist the temptation, to 
				improve human characteristics, such as size of memory, 
				resistance to disease, and length of life. Once such super 
				humans appear, there are going to be major political problems, 
				with the unimproved humans, who won't be able to compete. 
				
				 
				
				Presumably, they will die out, or 
				become unimportant. Instead, there will be a race of 
				self-designing beings, who are improving themselves at an 
				ever-increasing rate.
				
				If this race manages to redesign itself, to reduce or eliminate 
				the risk of self-destruction, it will probably spread out, and 
				colonize other planets and stars. However, long distance space 
				travel, will be difficult for chemically based life forms, like 
				DNA. The natural lifetime for such beings is short, compared to 
				the travel time. 
				 
				
				According to the theory of 
				relativity, nothing can travel faster than light. So the round 
				trip to the nearest star would take at least 8 years, and to the 
				centre of the galaxy, about a hundred thousand years. In science 
				fiction, they overcome this difficulty, by space warps, or 
				travel through extra dimensions. But I don't think these will 
				ever be possible, no matter how intelligent life becomes. In 
				the theory of relativity, if one can travel faster than 
				light, one can also travel back in time. 
				 
				
				This would lead to problems with 
				people going back, and changing the past. One would also expect 
				to have seen large numbers of tourists from the future, curious 
				to look at our quaint, old-fashioned ways.
				
				It might be possible to use genetic engineering, to make DNA 
				based life survive indefinitely, or at least for a hundred 
				thousand years. But an easier way, which is almost within our 
				capabilities already, would be to send machines. These could be 
				designed to last long enough for interstellar travel. When they 
				arrived at a new star, they could land on a suitable planet, and 
				mine material to produce more machines, which could be sent on 
				to yet more stars. 
				 
				
				These machines would be a new form 
				of life, based on mechanical and electronic components, rather 
				than macromolecules. They could eventually replace DNA based 
				life, just as DNA may have replaced an earlier form of life.
				
				This mechanical life could also be self-designing. Thus it seems 
				that the external transmission period of evolution, will have 
				been just a very short interlude, between the Darwinian phase, 
				and a biological, or mechanical, self design phase. This is 
				shown on this next diagram, which is not to scale, because 
				there's no way one can show a period of ten thousand years, on 
				the same scale as billions of years. 
				 
				
				How long the self-design phase 
				will last is open to question. It may be unstable, and life may 
				destroy itself, or get into a dead end. If it does not, it 
				should be able to survive the death of the Sun, in about 5 
				billion years, by moving to planets around other stars. Most 
				stars will have burnt out in another 15 billion years or so, and 
				the universe will be approaching a state of complete disorder, 
				according to the Second Law of Thermodynamics. 
				 
				
				But 
				
				Freeman Dyson has shown 
				that, despite this, life could adapt to the ever-decreasing 
				supply of ordered energy, and therefore could, in principle, 
				continue forever.
				
				What are the chances that we will encounter some alien form of 
				life, as we explore the galaxy. If the argument about the time 
				scale for the appearance of life on Earth is correct, there 
				ought to be many other stars, whose planets have life on them. 
				Some of these stellar systems could have formed 5 billion years 
				before the Earth. 
				 
				
				So why is the galaxy not crawling 
				with self designing mechanical or biological life forms? Why 
				hasn't the Earth been visited, and even colonized. I discount 
				suggestions that UFO's contain beings from outer space. I think 
				any visits by aliens, would be much more obvious, and probably 
				also, much more unpleasant.
				
				What is the explanation of why we have not been visited? One 
				possibility is that the argument, about the appearance of life 
				on Earth, is wrong. 
				 
				
				Maybe the probability of life 
				spontaneously appearing is so low, that Earth is the only planet 
				in the galaxy, or in the observable universe, in which it 
				happened. Another possibility is that there was a reasonable 
				probability of forming self reproducing systems, like cells, but 
				that most of these forms of life did not evolve intelligence. We 
				are used to thinking of intelligent life, as an inevitable 
				consequence of evolution. 
				 
				
				But the Anthropic Principle 
				should warn us to be wary of such arguments. 
				 
				
				It is more likely that evolution is 
				a random process, with intelligence as only one of a large 
				number of possible outcomes. It is not clear that intelligence 
				has any long-term survival value. Bacteria, and other single 
				cell organisms, will live on, if all other life on Earth is 
				wiped out by our actions. There is support for the view that 
				intelligence, was an unlikely development for life on Earth, 
				from the chronology of evolution. It took a very long time, two 
				and a half billion years, to go from single cells to multi-cell 
				beings, which are a necessary precursor to intelligence. 
				
				 
				
				This is a good fraction of the total 
				time available, before the Sun blows up. So it would be 
				consistent with the hypothesis, that the probability for life to 
				develop intelligence, is low. In this case, we might expect to 
				find many other life forms in the galaxy, but we are unlikely to 
				find intelligent life. 
				 
				
				Another way, in which life could 
				fail to develop to an intelligent stage, would be if an
				
				asteroid or comet were to collide with the 
				planet. We have just observed the collision of a 
				comet, Schumacher-Levi, with Jupiter. It produced a series of 
				enormous fireballs. It is thought the collision of a rather 
				smaller body with the Earth, about 70 million years ago, was 
				responsible for the extinction of the dinosaurs. 
				 
				
				A few small early mammals survived, 
				but anything as large as a human, would have almost certainly 
				been wiped out. It is difficult to say how often such collisions 
				occur, but a reasonable guess might be every twenty million 
				years, on average. If this figure is correct, it would mean that 
				intelligent life on Earth has developed only because of the 
				lucky chance that there have been no major collisions in the 
				last 70 million years. 
				 
				
				Other planets in the galaxy, on 
				which life has developed, may not have had a long enough 
				collision free period to evolve intelligent beings.
				
				A third possibility is that there is a reasonable probability 
				for life to form, and to evolve to intelligent beings, in the 
				external transmission phase. But at that point, the system 
				becomes unstable, and the intelligent life destroys itself. This 
				would be a very pessimistic conclusion. I very much hope it 
				isn't true. 
				 
				
				I prefer a fourth possibility:
				
				there are other forms of intelligent life 
				out there, but that we have been overlooked. 
				
				 
				
				There used to be a project called 
				SETI, the search for extra-terrestrial intelligence. It 
				involved scanning the radio frequencies, to see if we could pick 
				up signals from alien civilizations. I thought this project was 
				worth supporting, though it was cancelled due to a lack of 
				funds. But we should have been wary of answering back, until we 
				have develop a bit further. 
				 
				
				Meeting a more advanced 
				civilization, at our present stage, might be a bit like the 
				original inhabitants of America meeting Columbus. I don't think 
				they were better off for it.
				
				That is all I have to say. 
				 
				
				Thank you for listening.