by Dr Mark Sircus
January 28, 2013
It is not every day that one’s medical work is confirmed so utterly.
On January 3rd of 2013
medical scientists published vindication for Dr.
and even more so for my own work, which favors oral and transdermal
use of bicarbonate instead of using it intravenously.
It is not only vastly less expensive to
use bicarbonate (baking soda) orally and transdermally in baths, but
it is safer and now proven to be effective.
I find it very gratifying to have written and published
Bicarbonate - Rich Man’s Poor Man’s Cancer Treatment. It is the
only complete medical review on the subject.
I hope it is clear to everyone, after
reading the research below from the mainstream of medical science,
the importance of becoming familiar with bicarbonate medicine and
what it can do for cancer, kidney and diabetic patients as well as
for those seeking relief from the worst symptoms of the flu.
“The results of this study suggest
that tumor cells do, indeed, perform niche engineering by
creating an acidic environment that is non-toxic to the
malignant cells but, through its negative effects on normal
cells and tissue, promotes local invasion.”
The great advantage to using bicarbonate
orally (reinforced by strong magnesium and bicarbonate baths) is
that one can dose during all the waking hours and receive a full
course of treatment in about ten days.
Anyone can drive up their pH and
saturate all their cells to a much higher extent through these
methods. This is in contrast to Dr. Simoncini’s method that uses the
blood for delivery and thus changing the pH is strictly limited by
enforced blood parameters.
Exactly how high the pH is driven up using bicarbonate orally can be
controlled simply by using pH test strips.
One can do this continuously for up to
ten days keeping the optimal anti-cancer pH level constant. Using
sodium and potassium bicarbonates (seawater offers a parallel
reinforcing treatment) involves increasing carbon dioxide levels,
which increases oxygen levels as well as cell voltage - something
not generally known or understood.
This is the abstract for Dr. Robert J. Gillies and team from
Wayne State University School of Medicine paper, “Acidity
generated by the tumor microenvironment drives local invasion.”
The pH of solid tumors is acidic due
to increased fermentative metabolism and poor perfusion. It has
been hypothesized that acid pH promotes local invasive growth
and metastasis. The hypothesis that acid mediates invasion
proposes that H+ diffuses from the proximal tumor
microenvironment into adjacent normal tissues where it causes
tissue remodeling that permits local invasion.
In the current work, tumor invasion and peritumoral pH were
monitored over time using intravital microscopy. In every case,
the peritumoral pH was acidic and heterogeneous and the regions
of highest tumor invasion corresponded to areas of lowest pH.
Tumor invasion did not occur into
regions with normal or near-normal pH. Immunohistochemical
analyses revealed that cells in the invasive edges expressed the
glucose transporter GLUT-1 and the sodium-hydrogen exchanger
NHE-1, both of which were associated with peritumoral acidosis.
In support of the functional importance of our findings, oral
administration of sodium bicarbonate was sufficient to increase
peritumoral pH and inhibit tumor growth and local invasion in a
preclinical model, supporting the acid-mediated invasion
In their discussions these researchers
summarize the basic mechanisms of pH and cancer virility:
The propensity of cancers to invade
adjacent normal tissues contributes significantly to local tumor
growth and formation of metastases, which are largely
responsible for tumor-associated morbidity and mortality.
The mechanisms by which tumor cells
invade are complex and can be modified in response to
Due to increased glucose metabolism,
H+ production and excretion are generally increased in cancers.
This, combined with poor perfusion, results in an acidic
extracellular pH in malignant tumors (pH = 6.5-6.9) compared to
normal tissue under physiologic conditions (pH = 7.2-7.4).
Cancer cells, because of their enhanced evolutionary capacity,
develop adaptive mechanisms that allow them to survive and even
proliferate in acidic environments. Extracellular pH of tumors
is typically highly acidic, and this will inevitably result in
acid diffusion into the surrounding stroma.
We propose that the acidic pH of the tumor microenvironment
represents a “niche engineering” strategy that promotes local
invasion and subsequent in vivo growth of malignant tumors.
Support for this model has come from
recent observations that neutralization of the tumor derived
acid with systemic buffers (e.g. bicarbonate, imidazole,
lysine), can inhibit spontaneous and experimental metastases.
Acidity generated by the tumor
microenvironment drives local Invasion
- Veronica Estrella, Tingan Chen, Mark Lloyd, et al; Cancer Res
Published OnlineFirst January 3, 2013;