06 August 2012
from IMVA Website
Gene mutations are part of the process of cancer, but mutations alone are not enough to cause cancer to take hold and spread, thus threatening people’s lives through domination of precious life resources (nutrition) as well as precious real estate where other healthy cells live.
Genes do become damaged and sustain mutations in some cells and not others during people’s lifetimes.
An oncogene - a gene that causes tumors
in animals and uncontrolled growth in cells in culture - cannot in
and of itself change cells from normal to cancerous. It is the
cells’ surroundings, known as its
microenvironment, that contribute
in some way to how cancer has occurred.
interactions between cancer cells and their micro and macroenvironments create a context that promotes tumor growth and
protects them from immune attack or, on the other hand, prevent
tumors from making any kind of beachhead so they cannot take hold or
spread themselves around. Cancer cells routinely form in most
people’s bodies but that does not mean they are going to succeed in
capturing their host’s valuable resources so they can invade (inland
so to speak) as they win their war and take our life.
The microenvironment includes a complex scaffolding on which cells grow and develop, called the extracellular matrix. The microenvironment is what actually surrounds a cell.
The extracellular matrix (microenvironment) has been shown to regulate gene expression so it has more to do with the state of cancer than the cancer cells themselves.
Dr. Bissell and her students tested that hypothesis with some malignant cells, growing them on a healthy scaffolding.
And yes, they were able to
revert the malignant phenotype to a normal one. They could even
inject the cells into mice where they didn’t cause tumors, unlike
malignant cells, which would cause cancer. This, says Bissell,
indicates that there is another way to look at cancer - that cancer
genes are regulated by the environment around them.
It is not just the other surrounding cells but also the interstitial environment, which of course would include pH and nutrient levels being supplied by the blood. That may be why autopsies repeatedly find that most people who die of causes other than cancer have at least some tiny tumors in their bodies that had gone unnoticed.
According to current thinking, the tumors were kept in check, causing no harm.
Dr. Bissell is now hailed as a hero, with an award named after her.
Experiments that point to a new understanding of cancer
Dr. D.W. Smithers, then at Royal Marsden Hospital in London, argued that cancer was not a disease caused by a rogue cell that divides and multiplies until it destroys its host.
The death rate has barely budged for most cancers, and the gene mutation strategy so far has been a failure - a senseless one that has been used to reinforce the insane and very deadly form of medicine contemporary oncologists practice.
David Agus, a
conventional oncologist, agrees that cancer treatments have a
shortsighted focus on individual cells.
In that chapter I use military terminology
and imagery and we know what happens when we reinforce the troops
that surround an enemy.
There is coherence to the entire colony of cells until what we call
cancer occurs and then that coherence begins to break down.
We are beginning to see clinical evidence across the board show that what happens to healthy cells during cancer treatment determines much if not the entire outcome of treatment.
In other words, the same cancer cell,
when exposed to different “neighborhoods,” may have very different
responses to treatment.
The researchers observed up to 30-fold increases in WNT production!
The protein was taken up by tumor cells neighboring the damaged cells.
Rates of tumor cell reproduction have been shown to accelerate between chemotherapy treatments.
The researchers said they
confirmed their findings with breast and ovarian cancer tumors.
treatments for common solid tumors are given in smaller doses and in
cycles, or intervals, to allow the normal cells to recover. This
approach may not eradicate all of the tumor cells, and those that
survive can evolve to become resistant to subsequent rounds of
Instead of trying to kill the cancer and harm the surrounding cells we imprison the cancer in a solid wall of healthy cells, thus that area being strengthened as opposed to being weakened by treatments.
We create the conditions where we first limit the ability to grow and then send in some cruise missiles that directly target the cancer cells, choking the life out of them with waves of increased alkalinity and oxygen.
Read also "Chemotherapy Can Backfire and Boost Cancer Growth."