January 11, 2012
Vitamin B-12 is one of 8 B complex vitamins.
It is found in animal products such as meat, eggs, milk
and fish. Obviously a problem if you are vegetarian or vegan!
Deficiencies are associated with chronic diseases such as,
If you take drugs for diabetes, stomach
acid, ulcers, blood pressure, birth control or cholesterol you are
likely to be deficient too.
As you age you lose the ability to secret hydrochloric acid that helps to release Vitamin B-12 from your food. To further exacerbate the problem it is hard to absorb through the stomach so even if you are eating foods or taking supplements that are rich in Vitamin B-12 it is unlikely that you are getting enough.
You would only absorb around 1% at best
from a capsule supplement dose.
Cobalamin (cbl) absorption and metabolic pathway.
(A) Structure of cobalamin (vitamin B12) with a corrin ring bound to a central cobalt atom.
(B) The metabolic journey of cbl from nutrient intake to its intestinal absorption.
Endocytic receptors and proteins responsible for vitamin B12 intestinal absorption include
cubilin (CUBN), amnionless (AMN), receptor-associated protein (RAP) and megalin (LRP-2).
The membrane megalin/transcobalamin II (TCII) receptor complex allows the cellular uptake of cbl.
Lysosomal-mediated degradation of TCII and subsequent release of free cbl
is essential for vitamin B12 metabolic functions.
MS: methonine synthase;
MTHFR: methyltetrahydrofolate reductase;
MCM: methylmalonyl coA mutase.
This is a vitamin that is known to supply us with energy but it is
also good for the formation of your red blood cells and the support
of your immune system. It also helps your body produce melatonin
that helps you sleep so if you have difficulty sleeping you may
benefit from more B-12.
It may also be a factor in babies who show ‘failure to thrive’.
Lack of B-12 can lead to children being
neurologically impaired because they need B-12 for the development of
their neurological and hematological systems. There are three
reported cases of children dying of B-12 deficiency so it’s pretty
You can learn more about it by clicking here.
There are a number of B-12 sprays
available but I take this one because it seems to have a reasonable
price and because I trust Dr. Mercola as the source.